As with any beta, we recommend to be careful when installing macOS betas as they can break at any time and cause problems with apps you rely on.
Here is the latest status for our apps running on macOS 12 Beta 4 (Aug 2, 2021):
No issues found so far.
Screens Connect and Screens Express
macOS 12 Beta has a bug in an API we use, which will cause port mapping to fail and make your Mac unreachable remotely. We recommend to wait before installing macOS 12 beta.